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Anti-ICK Antibody FL594 Conjugate

Our Anti-ICK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N451/73. It detects mouse and rat ICK, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Serine/threonine-protein kinase ICK is encoded by the gene Ick. Ick is a member of the protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily. Ick has an essential role in ciliogenesis. Ick is envolved in the control of ciliary length by regulating the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. Ick is highly expressed in the colon and lungs, with lower levels of expression in the heart, esophagus, stomach, small intestine, and ovaries. Diseases associated with Ick include endocrine-cerebroosteodysplasia, juvenile myoclonic epilepsy 10, and juvenile myoclonic epilepsy 1.

Short Description

Our Anti-ICK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N451/73. It detects mouse and rat ICK, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Serine/threonine-protein kinase ICK (EC 2.7.11.1) (Intestinal cell kinase) (mICK) (MAK-related kinase) (MRK)

Gene Name

Ick

UniProt

Q9JKV2

Host

Mouse

Reactivity

Mouse and Rat

Immunogen

Fusion protein amino acids 290-629 (C-terminus) of mouse ICK (accession number Q9JKV2) produced recombinantly in E. Coli

Target

ICK

Clonality

Monoclonal

Isotype

IgG1

Clone

N451/73

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Rare Diseases

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

70 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Mouse

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

IHC Quality Control

1

RRID

AB_2940458

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