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Anti-MECP2 Antibody FL650 Conjugate

Our Anti-MECP2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N227/21. It detects human, mouse, and rat MECP2, and is purified by Protein A chromatography. It is great for use in DB, IHC.

Product Specifications

Background

MeCP2 (Methyl-CpG Binding Protein 2) is a chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair and is not influenced by sequences flanking the methyl-CpGs. MeCP2 has been shown to mediate transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A (Nan et al., 1998) . Defects in MeCP2 are the cause of Rett syndrome (RTT) (Amir et al., 1999) . RTT is an X-linked dominant disease; it is a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.

Short Description

Our Anti-MECP2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N227/21. It detects human, mouse, and rat MECP2, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)

Gene Name

MECP2

UniProt

P51608

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Synthetic peptide amino acids 157-169 (FTVTG[dimethyl-R]GSPSRRE) of human MECP2 (accession number P51608)

Target

MECP2

Clonality

Monoclonal

Isotype

IgG1

Clone

N227/21

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Rare Diseases

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

75 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Reacts preferentially with dimethylated peptide than with unmethylated peptide

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

IHC Quality Control

1

RRID

AB_2939983

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