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Anti-Frataxin Antibody FL550 Conjugate

Our Anti-Frataxin mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N191/7. It detects human Frataxin, and is purified by Protein A chromatography. It is great for use in ICC.

Product Specifications

Background

Frataxin is a highly conserved protein found in mitochondria. Frataxin is found many tissues including heart, spinal cord, liver, pancreas, dermal fibroblasts, peripheral blood lymphocytes and skeletal muscles. Frataxin functions as an iron chaperone involved in iron-sulfur biogenesis and heme biosynthesis and plays a role in iron homeostasis. Mutations in the Frataxin gene can result in Friederich ataxia.

Short Description

Our Anti-Frataxin mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N191/7. It detects human Frataxin, and is purified by protein a chromatography. It is great for use in ICC.

Synonyms

Frataxin, mitochondrial (EC 1.16.3.1) (Friedreich ataxia protein) (Fxn) [Cleaved into: Frataxin intermediate form (i-FXN) ; Frataxin (56-210) (m56-FXN) ; Frataxin (78-210) (d-FXN) (m78-FXN) ; Frataxin mature form (Frataxin (81-210) ) (m81-FXN) ]

Gene Name

FXN FRDA X25

UniProt

Q16595

Host

Mouse

Reactivity

Human

Immunogen

Fusion protein amino acids 81-210 (C-terminus) of human Frataxin (accession number Q16595) produced recombinantly in E. Coli

Target

Frataxin

Clonality

Monoclonal

Isotype

IgG2b

Clone

N191/7

Type

Primary Antibody

Applications

ICC

Field of Research

Mitochondrial Biology/Rare Diseases

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

25 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

ICC Quality Control

1

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

RRID

AB_2939769

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