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Anti-Nav1.7 Na+ Channel Antibody FL650 Conjugate

Our Anti-Nav1.7 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N68/6. It detects human, mouse, and rat Nav1.7 Na+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Nav1.7 subunit alpha, or SCN9A, is a member of the voltage gated sodium channel family. It is expressed at the terminal ends of sensory neurons in the dorsal root ganglion (DRG) and in trigeminal and sympathetic ganglion neurons. A major function of Nav1.7 is the generation and conduction of action potentials in nociceptors, or “pain receptors” and thus involved in pain sensation. Changes in Nav1.7 expression have been linked to primary erythermalgia, primary erythermalgia, and Congenital insensitivity to pain

Short Description

Our Anti-Nav1.7 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N68/6. It detects human, mouse, and rat Nav1.7 Na+ channel, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7)

Gene Name

SCN9A NENA

UniProt

Q15858

Host

Mouse

Reactivity

Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 1751-1946 (cytoplasmic C-terminus) of human Nav1.7 (accession number Q15858) produced recombinantly in E. Coli

Target

Nav1.7 Na+ channel

Clonality

Monoclonal

Isotype

IgG1

Clone

N68/6

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Ion Channels and Modulators/Na+ Channels

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

230 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

No cross-reactivity against other Nav channels

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

ICC Quality Control

1

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

RRID

AB_2939387

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