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Anti-KCC2 Antibody FL490 Conjugate

Our Anti-KCC2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N1/66. It detects chicken, human, mouse, and rat KCC2, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Product Specifications

Background

Solute carrier family 12 member 5 is encoded by the gene SLC12A5 and belongs to the SLC12 family of cation-coupled chloride transporters. SLC12A5 is an integral membrane K-Cl cotransporter that mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl (-) homeostasis. Diseases associated with SLC12A5 include Early Infantile Epileptic Encephalopathy 34 and Idiopathic Generalized Epilepsy 14.

Short Description

Our Anti-KCC2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N1/66. It detects chicken, human, mouse, and rat KCC2, and is purified by protein a chromatography. It is great for use in IHC, ICC.

Synonyms

Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (mKCC2) (Neuronal K-Cl cotransporter)

Gene Name

Slc12a5 Kcc2 Kiaa1176

UniProt

Q63633

Host

Mouse

Reactivity

Chicken, Human, Mouse, and Rat

Immunogen

Fusion protein amino acids 932-1043 (intracellular carboxyl terminus) of rat KCC2b (accession number Q63633) produced recombinantly in E. Coli

Target

KCC2

Clonality

Monoclonal

Isotype

IgG1

Clone

N1/66

Type

Primary Antibody

Applications

IHC, ICC

Field of Research

Transporter Proteins

Concentration

0.5 mg/mL

Format

Purified by Protein A chromatography

Buffer

PBS with 0.09% azide

Molecular Weight

140 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Specificity

Does not react with KCC1, KCC3 or KCC4

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Rat

WB Brain Quality Control

1

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

RRID

AB_2939220

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