Ketorolac (tromethamine salt)

Ketorolac tromethamine salt (RS37619 tromethamine salt) is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.

Product Specifications

CAS Number

[74103-07-4]

Product Name Alternative

Ketorolac Tromethamine; Ketorolac tris salt; RS37619 tromethamine salt

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

COX

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cancer

Assay Protocol

https://www.medchemexpress.com/Ketorolac-tromethamine-salt.html

Purity

99.91

Solubility

DMSO : ≥ 30 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(C1C2=CC=C(C(C3=CC=CC=C3)=O)N2CC1)O.OCC(CO)(N)CO

Molecular Formula

C19H24N2O6

Molecular Weight

376.40

Precautions

H301, H315, H319, H335

References & Citations

[1]Waterbury LD, et al. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22 (6) :1133-40.|[2]Fracon RN, et al. Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats. J Appl Oral Sci. 2010 Dec;18 (6) :630-4.|[3]Hsieh YC, et al. Intrathecal ketorolac pretreatment reduced spinal cord ischemic injury in rats. Anesth Analg. 2005 Apr;100 (4) :1134-9.