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Anti-Pregnancy Associated Plasma Protein A (PAPP-A) Antibody

Our mouse Pregnancy Associated Plasma Protein A (PAPP-A) monoclonal antibody from Antibodies Incorporated is produced in-house from clone 9. It detects human Pregnancy Associated Plasma Protein A (PAPP-A) and is Protein A or Protein G purified. Works in ELISA, IHC, WB.

Product Specifications

Background

Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21) .

Synonyms

PAPPA, ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1, pappalysin-1, IGF-dependent IGFBP-4 protease, aspecific BCL2 ARE-binding protein 2, differentially placenta 1 expressed protein, insulin-like growth factor-dependent IGF binding protein-4 protease, pregnancy-associated plasma protein A, pappalysin 1

Gene Name

PAPPA

NCBI Gene ID

5069

UniProt

Q13219

Host

Mouse

Reactivity

Human

Immunogen

Purified human PAPP-A

Target

Pregnancy Associated Plasma Protein A (PAPP-A)

Clonality

Monoclonal

Isotype

IgG2b κ

Clone

9

Type

Primary Antibodies

Applications

ELISA, IHC, WB

Concentration

1 mg/mL ±15%

Format

Protein A or Protein G purified

Buffer

0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Molecular Weight

500 kDa (tetramer), 180 kDa (monomer)

Shipping Conditions

Shipped on ice packs

Storage Conditions

2-8°C without exposure to light

Notes

BSA free

Specificity

BTE 004-09 is specific for native human PAPP-A. Heat and SDS denatured PAPP-A is also recognized, but not acid treated PAPP-A. The epitope of BTE 004-09 is different from ABS 006-01 and ABS 006-24. The epitope is located on the PAPP-A subunit of the heterotetramer.

Brand

Antibodies Inc (via BioPorto acquisition)

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

Frequently Asked Questions

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