CDK8 ligand 1

CDK8 ligand 1 is the ligand of CDK8. CDK8 ligand 1 can be used to synthesize LL-K8-22 (HY-149209) [1].

Product Specifications

CAS Number

[2924557-38-8]

UNSPSC

12352005

Target

CDK; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk8-ligand-1.html

Purity

98.0

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(CN1C=C(C2=CC=C(C3=CN=CC4=CC=CC=C43)C=C2)C=N1)N5CCNCC5

Molecular Formula

C24H23N5O

Molecular Weight

397.47

References & Citations

[1]Wang M, et al. Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex. J Med Chem. 2023 Apr 13;66 (7) :4932-4951.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK8

Available Sizes

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