CDK8 ligand 1
CDK8 ligand 1 is the ligand of CDK8. CDK8 ligand 1 can be used to synthesize LL-K8-22 (HY-149209) [1].
Product Specifications
CAS Number
[2924557-38-8]
UNSPSC
12352005
Target
CDK; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk8-ligand-1.html
Purity
98.0
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(CN1C=C(C2=CC=C(C3=CN=CC4=CC=CC=C43)C=C2)C=N1)N5CCNCC5
Molecular Formula
C24H23N5O
Molecular Weight
397.47
References & Citations
[1]Wang M, et al. Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex. J Med Chem. 2023 Apr 13;66 (7) :4932-4951.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK8
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
bsm-62430R-PerCP-Cy5.5 100 µL
Crotonyl-Histone H2B type 2E (Lys12) Recombinant Antibody, PerCP-Cy5.5 Conjugated
Ask
View Details