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Anti-HLA-DOB Antibody Picoband® APC Conjugated

Product Specifications

Background

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

Synonyms

HLA-DOB; HLA class II histocompatibility antigen, DO beta chain; MHC class II antigen DOB

UNSPSC

41116129

HS Code

3002.1

Gene Name

HLA-DOB

Gene ID

3112

UniProt

P13765

Host

Rabbit

Reactivity

Human, Mouse, Rat

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

E.coli-derived human HLA-DOB recombinant protein (Position: R18-C273) .

Clonality

Polyclonal

Applications

Recommended applications are based on the parent unconjugated antibody. Customers may select suitable applications according to their experimental needs.

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Liquid

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Storage Conditions

At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

31 kDa

Applications Notes

Optimal dilutions should be determined by end users.

Gene Name Synonym

Major histocompatibility complex, class II, DO beta

Protein Name

HLA class II histocompatibility antigen, DO beta chain

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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