Tinodasertib
Tinodasertib (ETC-206) is a selective MNK1 and MNK2 inhibitor with IC50s of 64 nM and 86 nM, respectively.
Product Specifications
CAS Number
[1464151-33-4]
Product Name Alternative
ETC-206
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tinodasertib.html
Purity
99.69
Solubility
DMSO : ≥ 50 mg/mL
Smiles
N#CC1=CC=C(C2=CN=C3C=CC(C4=CC=C(C(N5CCOCC5)=O)C=C4)=CN32)C=C1
Molecular Formula
C25H20N4O2
Molecular Weight
408.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Yang H, et al. Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia. J Med Chem. 2018 May 24;61 (10) :4348-4369.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MNK1; MNK2
Available Sizes
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