Kisspeptin-54 (human) (TFA)

Kisspeptin-54 (human) TFA (Metastin (human) TFA) is an endogenous ligand for kisspeptin receptor (KISS1, GPR54) . Kisspeptin-54 (human) TFA binds to rat and human GPR54 receptors with Ki values of 1.81 nM and 1.45 nM, respectively. Kisspeptin-54 (human) TFA hinders tumor metastasis and stimulates gonadotropin secretion[1][2].

Product Specifications

Product Name Alternative

Metastin (human) (TFA)

UNSPSC

12352209

Target

GnRH Receptor

Type

Peptides

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/kisspeptin-54-human-tfa.html

Purity

98.86

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(N3[C@@H](CCC3)C(N[C@@H](CCC(O)=O)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N4[C@@H](CCC4)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](C)C(N5[C@@H](CCC5)C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CO)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)CC)C(N7[C@@H](CCC7)C(N[C@@H](C)C(N8[C@@H](CCC8)C(N[C@@H](CCC(N)=O)C(NCC(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N9[C@@H](CCC9)C(N[C@@H](CC(N)=O)C(N[C@@H](CC%10=CC=C(C=C%10)O)C(N[C@@H](CC(N)=O)C(N[C@@H](CC%11=CNC%12=CC=CC=C%11%12)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CC%13=CC=CC=C%13)C(NCC(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC%14=CC=CC=C%14)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CN.OC(C(F)(F)F)=O

Molecular Formula

C258H401N79O78.C2HF3O2

Molecular Weight

5971.45

References & Citations

[1]M L Gottsch, et al. A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse. Endocrinology. 2004 Sep;145 (9) :4073-7.|[2]M Kotani, et al. The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-Coupled Receptor GPR54. J Biol Chem. 2001 Sep 14;276 (37) :34631-6.