BE1218
BE1218 is a liver X receptor (LXR) inverse agonist with IC50 values of 9 nM and 7 nM against LXRα and LXRβ, respectively[1].
Product Specifications
CAS Number
[2893967-40-1]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
LXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/be1218.html
Purity
99.86
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CC(C)=C(C(C)=C1)S(=O)(N(CC2=C(C=CC=C2)F)CC3=CC=C(C=C3)C4=CC(S(C)(=O)=O)=CC=C4)=O
Molecular Formula
C30H30FNO4S2
Molecular Weight
551.69
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Elgendy B, et al. Synthesis and structure activity relationship of the first class of LXR inverse agonists. Bioorg Chem. 2022 Feb;119:105540.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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