Ethyl linoleate

Ethyl linoleate (Linoleic Acid ethyl ester) is an orally active unsaturated fatty acid. Ethyl linoleate inhibits the Akt/GSK3β/β-catenin signaling pathway and the activation of NF-κB. Ethyl linoleate induces heme oxygenase-1 and inhibits tyrosinase. Ethyl linoleate has whitening and anti-inflammatory effects. Ethyl linoleate promotes compound absorption. Ethyl linoleate has a significant influence on atherosclerosis. Ethyl linoleate is used in the research of inflammatory diseases. Ethyl linoleate can be used in cosmetics[1][2][3][4][5][6]

Product Specifications

CAS Number

[544-35-4]

Product Name Alternative

Linoleic Acid ethyl ester; Mandenol

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Akt; Biochemical Assay Reagents; GSK-3; Heme Oxygenase (HO) ; NF-κB; Tyrosinase; β-catenin

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; NF-κB; Others; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ethyl-linoleate.html

Concentration

10mM

Purity

99.72

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCC/C=C\C/C=C\CCCCCCCC(OCC)=O

Molecular Formula

C20H36O2

Molecular Weight

308.50

Precautions

H302, H315, H319, H335

References & Citations

[1]Hyun Jung Koo, et al. Chinese yam extracts containing β-sitosterol and ethyl linoleate protect against atherosclerosis in apolipoprotein E-deficient mice and inhibit muscular expression of VCAM-1 in vitro. J Food Sci. 2014 Apr;79 (4) :H719-29.|[2]Ko GA, et al. Ethyl linoleate inhibits α-MSH-induced melanogenesis through Akt/GSK3β/β-catenin signal pathway. Korean J Physiol Pharmacol. 2018 Jan;22 (1) :53-61.|[3]Park SY, et al. Ethyl linoleate from garlic attenuates lipopolysaccharide-induced pro-inflammatory cytokine production by inducing heme oxygenase-1 in RAW264.7 cells. Int Immunopharmacol. 2014 Apr;19 (2) :253-61.|[4]Wu W, et al. Enhanced bioavailability of silymarin by self-microemulsifying drug delivery system. Eur J Pharm Biopharm. 2006 Jul;63 (3) :288-94.|[5]Zhu JX, et al. Development of self-microemulsifying drug delivery system for oral bioavailability enhancement of berberine hydrochloride. Drug Dev Ind Pharm. 2013 Mar;39 (3) :499-506.|[6]Osumi Y, et al. Effects of ethyl-linoleate on the atheromatous changes caused by high cholesterol diet in the rabbit. Jpn J Pharmacol. 1966 Mar;16 (1) :83-91.