L-Leucine

L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

Product Specifications

CAS Number

[61-90-5]

Product Name Alternative

Leucine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; mTOR

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/L-Leucine.html

Purity

99.90

Solubility

H2O : 8.33 mg/mL (ultrasonic)

Smiles

N[C@@H](CC(C)C)C(O)=O

Molecular Formula

C6H13NO2

Molecular Weight

131.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9 (10) :e1003857.|[2]Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond) . 2012 Aug 22;9 (1) :77.|[3]Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61 (2) :409-17.