Amantadine (hydrochloride) (Standard)

Amantadine (hydrochloride) (Standard) is the analytical standard of Amantadine (hydrochloride) . This product is intended for research and analytical applications. Amantadine (1-Adamantanamine) hydrochloride is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine hydrochloride inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine hydrochloride also has anti-orthopoxvirus and anticancer activity. Amantadine hydrochloride can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[1][2][3][4][5][6].

Product Specifications

CAS Number

[665-66-7]

Product Name Alternative

1-Adamantanamine hydrochloride (Standard) ; 1-Adamantylamine hydrochloride (Standard) ; 1-Aminoadamantane hydrochloride (Standard)

UNSPSC

12352211

Hazard Statement

H302

Target

Apoptosis; Bcl-2 Family; CDK; Influenza Virus; Orthopoxvirus; Reference Standards; SARS-CoV

Type

Reference Standards

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Others

Field of Research

Cancer; Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/amantadine-hydrochloride-standard.html

Purity

99.83

Smiles

NC1(C2)C[C@@H]3C[C@@H](C[C@H]2C3)C1.Cl

Molecular Formula

C10H18ClN

Molecular Weight

187.71

Precautions

P264-P270-P330-P501

References & Citations

[1]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9 (3) :195-200.|[2]Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78 (14) :1096-1099.|[3]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57 (1-2) :41-52. |[4]Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 24;13 (4) :539. |[5]Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct;121 (4) :773-85. |[6]Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 2015;36 (3) :904-910.