ML327

ML327 is a blocker of MYC which can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT) .

Product Specifications

CAS Number

[1883510-31-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Autophagy; c-Myc

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ML327.html

Purity

98.02

Solubility

DMSO : 32 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=CC=CNC1=O)NCCCNC(C2=NOC(C3=CC=CC=C3)=C2)=O

Molecular Formula

C19H18N4O4

Molecular Weight

366.37

Precautions

H302

References & Citations

[1]Rellinger EJ, et al. Isoxazole compound ML327 blocks MYC expression and tumor formation in neuroblastoma. Oncotarget. 2017 Jul 20;8 (53) :91040-91051.|[2]An H, et al. Small molecule/ML327 mediated transcriptional de-repression of E-cadherin and inhibition of epithelial-to-mesenchymal transition.Oncotarget. 2015 Sep 8;6 (26) :22934-48.