BRD7116
BRD7116 is a cell-non-autonomous inhibitor of leukemic stem cells (LSCs) . BRD7116, without directly contacting LSCs, can inhibit LSCs merely by altering the microenvironment. BRD7116 also has any cell-autonomous effects on LSCs and induces transcriptional changes consistent with myeloid differentiation. BRD7116 can be used for the study of leukemia[1].
Product Specifications
CAS Number
[329059-55-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/BRD7116.html
Concentration
10mM
Purity
99.73
Solubility
DMSO : ≥ 48 mg/mL
Smiles
O=S(C1=CC=C(NC(C2C(C)(C)C2(C)C)=O)C=C1)(C3=CC=C(NC(C4C(C)(C)C4(C)C)=O)C=C3)=O
Molecular Formula
C28H36N2O4S
Molecular Weight
496.66
Precautions
H302, H315, H319, H335
References & Citations
[1]Hartwell KA, et al. Niche-based screening identifies small-molecule inhibitors of leukemia stem cells. Nat Chem Biol. 2013 Dec;9 (12) :840-848
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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