HN0037
HN0037 is a selective, orally active helicase-primase inhibitor. HN0037 is primarily metabolized by CYP3A4. HN0037 inhibits HSV replication by targeting the viral helicase-primase complex, which consists of three proteins encoded by the UL5 (helicase), UL52 (primase), and UL8 (a scaffold protein that promotes primer synthesis) genes[1].
Product Specifications
CAS Number
2233566-79-3
UNSPSC
12352005
Target
Cytochrome P450; HSV
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hn0037.html
Purity
99.46
Smiles
O=C(N(C1=NC(C)=C(S1)S(N)(=O)=O)C)[C@@H]2CC(C=CC(C3=CC=CC=N3)=C4)=C4C2
Molecular Formula
C20H20N4O3S2
Molecular Weight
428.53
References & Citations
[1]Hou J, et al. Pharmacokinetics and Safety Study of HN0037, a Novel Anti-Human Herpes Simplex Virus Inhibitor, in Healthy Volunteers. Clin Pharmacol Drug Dev. 2022 Dec;11 (12) :1467-1473.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP3
Available Sizes
Frequently Asked Questions
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