HN0037
HN0037 is a selective, orally active helicase-primase inhibitor. HN0037 is primarily metabolized by CYP3A4. HN0037 inhibits HSV replication by targeting the viral helicase-primase complex, which consists of three proteins encoded by the UL5 (helicase), UL52 (primase), and UL8 (a scaffold protein that promotes primer synthesis) genes[1].
Product Specifications
CAS Number
2233566-79-3
UNSPSC
12352005
Target
Cytochrome P450; HSV
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/hn0037.html
Purity
99.46
Smiles
O=C(N(C1=NC(C)=C(S1)S(N)(=O)=O)C)[C@@H]2CC(C=CC(C3=CC=CC=N3)=C4)=C4C2
Molecular Formula
C20H20N4O3S2
Molecular Weight
428.53
References & Citations
[1]Hou J, et al. Pharmacokinetics and Safety Study of HN0037, a Novel Anti-Human Herpes Simplex Virus Inhibitor, in Healthy Volunteers. Clin Pharmacol Drug Dev. 2022 Dec;11 (12) :1467-1473.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP3
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PKSH033175-01 10 µg
Recombinant Human UCHL1/PGP9.5 Protein (His Tag)
Sign In for Pricing
View Details PKSH033175-02 50 µg
Recombinant Human UCHL1/PGP9.5 Protein (His Tag)
Sign In for Pricing
View Details 
KN401610 1 Kit
ornithine aminotransferase (OAT) Human Gene Knockout Kit (CRISPR)
Sign In for Pricing
View Details 
GM-300-30 1 mL
Colloidal Gold Conjugated Sheep Affinity Purified Antibody to Mouse IgG1, 30nm
Sign In for Pricing
View Details 
LY420688 100 µg
C5ORF44 (TRAPPC13) (NM_001093755) Human Over-expression Lysate
Sign In for Pricing
View Details