PAK4-IN-2
Product Specifications
UNSPSC Description
PAK4-IN-2 is a highly potent PAK4 inhibitor with IC50 value of 2.7 nM. PAK4-IN-2 can arrest MV4-11 cells at G0/G1 phase and induce cell apoptosis. PAK4-IN-2 can be used for researching cancer[1].
Target Antigen
Apoptosis; PAK
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pak4-in-2.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CC(NC2=NC(N[C@H]3CC[C@@H](N)CC3)=C4C(NC=C4)=N2)=CC=C1
Molecular Weight
356.85
References & Citations
[1]Wang C, Xia J, Lei Y, et al. Synthesis and biological evaluation of 7H-pyrrolo [2,3-d] pyrimidine derivatives as potential p21-activated kinase 4 (PAK4) inhibitors. Bioorg Med Chem. 2022;60:116700.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143490/PAK4-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143490/PAK4-IN-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2488706-33-6
Available Sizes
Curated Selection
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