Foscarnet (sodium)

Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].

Product Specifications

CAS Number

[63585-09-1]

Product Name Alternative

Trisodium phosphonoformate; Phosphonoformic acid trisodium salt

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/foscarnet-sodium.html

Concentration

10mM

Purity

98.0

Solubility

H2O : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=P(O[Na])(O[Na])C(O[Na])=O

Molecular Formula

CNa3O5P

Molecular Weight

191.95

Precautions

H302, H315, H319, H335

References & Citations

[1]Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34 (2) :373-5.|[2]Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium) .Pharmacol Ther. 1982;19 (3) :387-415.|[3]Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24.