Danirixin
Danirixin is a selective, and reversible CXCR2 antagonist, with IC50 of 12.5 nM for CXCL8.
Product Specifications
CAS Number
[954126-98-8]
Product Name Alternative
GSK1325756
UNSPSC
12352005
Hazard Statement
H302
Target
CXCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Danirixin.html
Purity
98.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(Cl)C(S([C@H]2CCCNC2)(=O)=O)=C1O)NC3=C(C)C(F)=CC=C3
Molecular Formula
C19H21ClFN3O4S
Molecular Weight
441.90
Precautions
P264-P270-P330-P501
References & Citations
[1]Miller BE, et al. The pharmacokinetics and pharmacodynamics of danirixin (GSK1325756) --a selective CXCR2 antagonist?--in healthy adult subjects. BMC Pharmacol Toxicol. 2015 Jun 20;16:18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CXCR2
Available Sizes
Curated Selection
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