6-Mercaptopurine

6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug.

Product Specifications

CAS Number

[50-44-2]

Product Name Alternative

Mercaptopurine; 6-MP

UNSPSC

12352005

Hazard Statement

H301, H341, H361

Target

Autophagy; Endogenous Metabolite; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/6-Mercaptopurine.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 35.71 mg/mL (ultrasonic)

Smiles

S=C1NC=NC2=C1NC=N2

Molecular Formula

C5H4N4S

Molecular Weight

152.18

Precautions

H301, H341, H361

References & Citations

[1]Sahasranaman S, et al. Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64 (8) :753-67.|[2]Liu Q, et al. 6-Mercaptopurine augments glucose transport activity in skeletal muscle cells in part via a mechanism dependent upon orphan nuclear receptor NR4A3. Am J Physiol Endocrinol Metab. 2013 Nov 1;305 (9) :E1081-92.|[3]Kanemitsu H, et al. 6-Mercaptopurine (6-MP) induces cell cycle arrest and apoptosis of neural progenitor cells in the developing fetal rat brain. Neurotoxicol Teratol. 2009 Mar-Apr;31 (2) :104-9.