Maytansine

Maytansine is a highly potent microtubule-targeted compound that induces mitotic arrest and kills tumor cells at subnanomolar concentrations[1].

Product Specifications

CAS Number

[35846-53-8]

Product Name Alternative

NSC 153858

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Microtubule/Tubulin

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/maytansine.html

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@]12[C@@]([C@@H]([C@]3([H])C[C@]([C@@H](/C=C/C=C(CC4=CC(N(C(C[C@@H]2OC([C@H](C)N(C)C(C)=O)=O)=O)C)=C(C(OC)=C4)Cl)\C)OC)(NC(O3)=O)O)C)([H])O1

Molecular Formula

C34H46ClN3O10

Molecular Weight

692.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Lopus M, et al. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther. 2010;9 (10) :2689-2699.|[2]Remillard S, et al. Antimitotic activity of the potent tumor inhibitor maytansine. Science. 1975;189 (4207) :1002-1005.