N- (Azido-PEG4) -biocytin

N- (Azido-PEG4) -biocytin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N- (Azido-PEG4) -biocytin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[2055042-70-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-azido-peg4-biocytin.html

Purity

97.37

Solubility

10 mM in DMSO

Smiles

O=C(O)[C@H](CCCCNC(CCCC[C@@H]1SC[C@]([C@]1([H])N2)([H])NC2=O)=O)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O

Molecular Formula

C27H47N7O9S

Molecular Weight

645.77

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562