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BNN6

BNN6 is a thermoresponsive nitric oxide (NO) donor that often works by binding to a carrier. BNN6 decomposes under the heat stimulation generated by photothermal action, releasing high concentrations of NO, which exerts anti-tumor activity by inducing tumor cell apoptosis and inhibiting their repair. BNN6 can be used to synthesize the multifunctional biosensor BNN6-BiTiS3-iRGD, which exerts a synergistic anti-cancer effect with photothermal therapy (PTT) [1][2][3].

Product Specifications

CAS Number

106476-75-9

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bnn6.html

Purity

98.0

Solubility

DMSO : 175 mg/mL (ultrasonic)

Smiles

O=NN(C(C)CC)C1=CC=C(N(C(C)CC)N=O)C=C1

Molecular Formula

C14H22N4O2

Molecular Weight

278.35

References & Citations

[1]Jiang M, et al., BiTiS3 bio-transducer with explosive on-demand generation of NO gas for synergetic cancer therapy. Biosens Bioelectron. 2024 Feb 15;246:115895.|[2]Yang J, et al. Controlled Nitric Oxide-Releasing Nanovehicles for Enhanced Infected Wound Healing: A Study on PDA@BNN6 Encapsulated in GelMA Hydrogel. Int J Nanomedicine. 2024 Nov 8;19:11499-11516.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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