Lansoprazole sulfone-d4
Product Specifications
UNSPSC Description
Lansoprazole sulfone-d4 (AG-1813-d4) is the deuterium labeled Lansoprazole sulfone. Lansoprazole sulfone-d4 is an orally active and selective inhibitor of H+, K+-ATPase. Lansoprazole sulfone-d4 can significantly stimulates gastric acid secretion by inhibiting H+, K+-ATPase. Lansoprazole sulfone-d4 has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease[1][2][3].
Target Antigen
Isotope-Labeled Compounds; Proton Pump
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel;Others
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
CC(C(OCC(F)(F)F)=CC=N1)=C1CS(=O)(C2=NC3=C([2H])C([2H])=C([2H])C([2H])=C3N2)=O
Molecular Weight
389.39
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Swamy G, et al. Crystal structure of lansoprazole sulfone[J]. Journal of Structural Chemistry, 2007, 48: 715-718.|[3]Karol MD, et al. Lansoprazole pharmacokinetics in subjects with various degrees of kidney function. Clin Pharmacol Ther. 1997 Apr;61(4):450-8.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
1184999-77-6
Available Sizes
Curated Selection
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