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Lansoprazole sulfone-d4

Lansoprazole sulfone-d4 (AG-1813-d4) is the deuterium labeled Lansoprazole sulfone. Lansoprazole sulfone-d4 is an orally active and selective inhibitor of H+, K+-ATPase. Lansoprazole sulfone-d4 can significantly stimulates gastric acid secretion by inhibiting H+, K+-ATPase. Lansoprazole sulfone-d4 has potential applications in duodenal ulcer, gastric ulcer, gastroesophageal reflux disease and Zolinger Ellison disease[1][2][3].

Product Specifications

CAS Number

[1184999-77-6]

Product Name Alternative

AG-1813-d4

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Proton Pump

Type

Isotope-Labeled Compounds

Related Pathways

Membrane Transporter/Ion Channel; Others

Field of Research

Others

Solubility

10 mM in DMSO

Smiles

CC(C(OCC(F)(F)F)=CC=N1)=C1CS(=O)(C2=NC3=C([2H])C([2H])=C([2H])C([2H])=C3N2)=O

Molecular Formula

C16H10D4F3N3O3S

Molecular Weight

389.39

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Swamy G, et al. Crystal structure of lansoprazole sulfone[J]. Journal of Structural Chemistry, 2007, 48: 715-718.|[3]Karol MD, et al. Lansoprazole pharmacokinetics in subjects with various degrees of kidney function. Clin Pharmacol Ther. 1997 Apr;61 (4) :450-8.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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