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Anti-DNase I/DNASE1 Antibody Picoband® Cy3 Conjugated

Selected Variant

A02728-1-Cy3

Size: 100 µg/Vial

Product Specifications

Background

This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Synonyms

DNASE1; DNL1; DRNI; Deoxyribonuclease-1; EC 3.1.21.1; Deoxyribonuclease I; DNase I; Dornase alfa

UNSPSC

41116129

HS Code

3002.1

Gene Name

DNASE1

Gene ID

1773

UniProt

P24855

Host

Rabbit

Reactivity

Human

Cross Reactivity

No cross-reactivity with other proteins

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human DNase I/DNASE1.

Clonality

Polyclonal

Applications

Recommended applications are based on the parent unconjugated antibody. Customers may select suitable applications according to their experimental needs.

Purification

Immunogen affinity purified.

Concentration

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Form

Liquid

Reconstitution

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Storage Conditions

At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Calculated Molecular Weight

31 kDa

Applications Notes

Optimal dilutions should be determined by end users.

Gene Name Synonym

Deoxyribonuclease 1

Protein Name

Deoxyribonuclease-1

Isotype

Rabbit IgG

Contents

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.

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