Anti-SIGLEC6 Antibody Picoband® Cy3 Conjugated
Product Specifications
Background
Siglec-6, originally identified on trophoblast cells of the placenta, is highly and consistently expressed on MCs from both mucosal and non-mucosal sites. Siglec-6 consists of 3 extracellular immunoglobulin (Ig) domains and 2 intracellular immunoreceptor tyrosine-based inhibition motifs (ITIMs), closely resembling the molecular structure of Siglec-3 (CD33) (PMID: 34289026) . Siglec-6 was recruited to placental expression during human evolution, presumably to interact with sialylated ligands for specific negative signaling functions and/or to regulate leptin availability (PMID: 17580316) . Siglec-6 is an immunoreceptor tyrosine-based inhibitory motif (ITIM) -bearing receptor selectively expressed by mast cells, making it a promising target for therapeutic intervention (PMID: 35406705) .
Synonyms
SIGLEC6; OB-BP1; CD33L1; CD33L; CD33 antigen-like 1
UNSPSC
41116129
HS Code
3002.1
Gene Name
SIGLEC6
Gene ID
946
UniProt
O43699
Host
Rabbit
Reactivity
Human
Cross Reactivity
No cross-reactivity with other proteins
Immunogen
E.coli-derived human SIGLEC6 recombinant protein (Position: R18-D197) .
Clonality
Polyclonal
Applications
Recommended applications are based on the parent unconjugated antibody. Customers may select suitable applications according to their experimental needs.
Purification
Immunogen affinity purified.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Form
Liquid
Reconstitution
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Storage Conditions
At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.
Calculated Molecular Weight
50 kDa
Applications Notes
Optimal dilutions should be determined by end users.
Gene Name Synonym
Sialic acid binding Ig like lectin 6
Protein Name
Sialic acid-binding Ig-like lectin 6
Isotype
Rabbit IgG
Contents
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.
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