AK106-001616
AK106-001616 is a potent and selective inhibitor of cytosolic phospholipase A2 (cPLA2) (IC50=3.8 nmol/L) . AK106-001616 is able to reduce the production of prostaglandins (PG) E2 and leukotrienes (LT) B4 by stimulated cells. AK106-001616 can be used in the study of inflammatory diseases, neuropathic pain and pulmonary fibrosis[1].
Product Specifications
CAS Number
[590416-75-4]
UNSPSC
12352005
Target
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology; Neurological Disease; Others
Assay Protocol
https://www.medchemexpress.com/ak106-001616.html
Smiles
O=C(O)CCC1=CC(C2=CC3=C(N(C)N=C3)C=C2)=C(OC4CC5=C(C=CC=C5)C4)C(N)=C1
Molecular Formula
C26H25N3O3
Molecular Weight
427.50
References & Citations
[1]Shimizu, Hirotomo, et al. AK106-001616, a potent and selective inhibitor of cytosolic phospholipase A2: in vivo efficacy for inflammation, neuropathic pain, and pulmonary fibrosis. Journal of Pharmacology and Experimental Therapeutics 369.3 (2019) : 511-522.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
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