Aloenin

Aloenin (Aloenin A) is a kind of natural product, has effective clearing and free radical activity, and has moderate inhibitory activity on β-secretion (BACE) (IC50=14.95 μg/mL) . Aloenin suppresses peritoneal hypertrophy in large rats and suppresses its release[1][2][3][4].

Product Specifications

CAS Number

[38412-46-3]

Product Name Alternative

Aloenin A

UNSPSC

12352005

Target

Beta-secretase

Type

Natural Products

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/aloenin.html

Purity

99.91

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O[C@H]([C@@H](O)[C@@H]1O)[C@@H](O[C@@H]1CO)OC2=C(C(O3)=CC(OC)=CC3=O)C(C)=CC(O)=C2

Molecular Formula

C19H22O10

Molecular Weight

410.37

References & Citations

[1]Sun YN, et al. Antioxidant and anti-osteoporotic effects of anthraquinones and related constituents from the aqueous dissolved Aloe exudates. Nat Prod Res. 2017 Dec;31 (23) :2810-2813.|[2]Gao B, et al. Active constituents from Aloe arborescens as BACE inhibitors. Yao Xue Xue Bao. 2006 Oct;41 (10) :1000-3.|[3]Nakagomi K, et al. Inhibition by aloenin and barbaloin of histamine release from rat peritoneal mast cells[J]. Agricultural and biological chemistry, 1987, 51 (6) : 1723-1724.|[4]Deora N, et al. Lipase activity inhibited by aloenin A: Glycoside from Aloe vera (L.) Burm. f.-In vitro and molecular docking studies. J Mol Recognit. 2023 Feb;36 (2) :e3002.