Org-26576
Org-26576 is a AMPA receptor positive allosteric modulator.
Product Specifications
CAS Number
100044-96-0
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Org-26576.html
Purity
98.58
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1N2[C@](CCC2)([H])COC3=NC=CC=C13
Molecular Formula
C11H12N2O2
Molecular Weight
204.23
References & Citations
[1]Jordan GR, et al. Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography. Neuropharmacology. 2005 Aug;49 (2) :254-64.|[2]Su XW, et al. Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus. Psychopharmacology (Berl) . 2009 Oct;206 (2) :215-22.|[3]Fumagalli F, et al. The AMPA receptor potentiator Org 26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus. Pharmacol Res. 2012 Feb;65 (2) :176-81.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor
Available Sizes
Frequently Asked Questions
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