Org-26576

Org-26576 is a AMPA receptor positive allosteric modulator.

Product Specifications

CAS Number

[100044-96-0]

UNSPSC

12352005

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Org-26576.html

Purity

98.58

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1N2[C@](CCC2)([H])COC3=NC=CC=C13

Molecular Formula

C11H12N2O2

Molecular Weight

204.23

References & Citations

[1]Jordan GR, et al. Regionally selective and dose-dependent effects of the ampakines Org 26576 and Org 24448 on local cerebral glucose utilisation in the mouse as assessed by 14C-2-deoxyglucose autoradiography. Neuropharmacology. 2005 Aug;49 (2) :254-64.|[2]Su XW, et al. Chronic treatment with AMPA receptor potentiator Org 26576 increases neuronal cell proliferation and survival in adult rodent hippocampus. Psychopharmacology (Berl) . 2009 Oct;206 (2) :215-22.|[3]Fumagalli F, et al. The AMPA receptor potentiator Org 26576 modulates stress-induced transcription of BDNF isoforms in rat hippocampus. Pharmacol Res. 2012 Feb;65 (2) :176-81.