Neohesperidin

Neohesperidin is a flavonoid compound abundant in citrus plants with antioxidant and anti-inflammatory effects. Neohesperidin can upregulate the Wnt/β-catenin signaling pathway, enhance the nuclear translocation of β-catenin and the differentiation of bone marrow stromal cells[1].

Product Specifications

CAS Number

[13241-33-3]

Product Name Alternative

Hesperetin 7-O-neohesperidoside

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Wnt; β-catenin

Type

Natural Products

Related Pathways

Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Neohesperidin.html

Purity

98.67

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C[C@@H](C2=CC=C(OC)C(O)=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO)O4)O)O)O[C@@]5([H])[C@@H]([C@@H]([C@H]([C@H](C)O5)O)O)O)=CC(O)=C13

Molecular Formula

C28H34O15

Molecular Weight

610.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Lee JH, et al. Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease. Phytother Res. 2009 Dec;23 (12) :1748-53.|[2]Xu F, et al. Neohesperidin induces cellular apoptosis in human breast adenocarcinoma MDA-MB-231 cells via activating the Bcl-2/Bax-mediated signaling pathway. Nat Prod Commun. 2012 Nov;7 (11) :1475-8.|[3]Jia S, et al. Hypoglycemic and hypolipidemic effects of neohesperidin derived from Citrus aurantium L. in diabetic KK-A (y) mice. Food Funct. 2015 Mar;6 (3) :878-86.|[4]Yuan S, et al. Neohesperidin promotes the proliferation and osteogenic differentiation of BMSCs via BMP2-Wnt/β-catenin pathway. Cell Cycle. 2022 Jan;21 (2) :187-201.