C215
C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis, limited non-specific toxicity against mammalian cells, an IC90 of 16 μM against M. tuberculosis, and efficacy against M. tuberculosis growing in macrophages[1].
Product Specifications
CAS Number
912780-51-9
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/c215.html
Purity
99.63
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CCCN1C2=CC=C(NCC3=CC=C(Cl)C=C3Cl)C=C2N=C1
Molecular Formula
C17H17Cl2N3
Molecular Weight
334.24
References & Citations
[1]Stanley SA, Grant SS, Kawate T, et al. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol. 2012;7 (8) :1377-1384.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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