C215

C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis, limited non-specific toxicity against mammalian cells, an IC90 of 16 μM against M. tuberculosis, and efficacy against M. tuberculosis growing in macrophages[1].

Product Specifications

CAS Number

[912780-51-9]

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/c215.html

Purity

99.63

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CCCN1C2=CC=C(NCC3=CC=C(Cl)C=C3Cl)C=C2N=C1

Molecular Formula

C17H17Cl2N3

Molecular Weight

334.24

References & Citations

[1]Stanley SA, Grant SS, Kawate T, et al. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol. 2012;7 (8) :1377-1384.