CGP 12177 (hydrochloride)

CGP 12177 ((±) -CGP 12177) hydrochloride is a β-Adrenergic receptor (β-AR) ligand. CGP 12177 hydrochloride is a β3-AR (Ki = 88 nM) agonist with β1/β2-AR (Ki = 0.9 nM for β1; Ki = 4 nM for β2) antagonist action. CGP 12177 hydrochloride exhibits partial agonist properties for α1-AR in rat pulmonary artery. CGP 12177 hydrochloride regulates the expression of ucp and leptin genes in NMRI mice adipose tissues. CGP 12177 hydrochloride can be used for cardiovascular and metabolic disease research[1][2][3][4].

Product Specifications

CAS Number

[64208-32-8]

Product Name Alternative

(±) -CGP 12177 (hydrochloride)

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cgp-12177-hydrochloride.html

Purity

99.69

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(OCC(O)CNC(C)(C)C)C=CC=C2N1.Cl

Molecular Formula

C14H22ClN3O3

Molecular Weight

315.80

References & Citations

[1]Leblais V, et al. Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery. J Pharmacol Exp Ther. 2004 Apr;309 (1) :137-45.|[2]Baker JG, et al. Pharmacological characterization of CGP 12177 at the human beta (2) -adrenoceptor. Br J Pharmacol. 2002 Oct;137 (3) :400-8.|[3]Oliver P, et al. In vivo effects of CGP-12177 on the expression of leptin and uncoupling protein genes in mouse brown and white adipose tissues. Int J Obes Relat Metab Disord. 2000 Apr;24 (4) :423-8.|[4]Strosberg AD, et al. Function and regulation of the beta 3-adrenoceptor. Trends Pharmacol Sci. 1996 Oct;17 (10) :373-81.