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Anti-GFAP (N206A/8) Recombinant Guinea Pig Chimeric mAb

Our guinea pig Anti-GFAP recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N206A/8. It is KO validated, detects drosophila, guinea pig, human, mouse, polar bear, and rat GFAP and is purified by affinity chromatography. It works in ELISA, ICC, IHC, WB.

Product Specifications

Background

Glial fibrillary acidic protein (GFAP) is an intermediate filament with many different isoforms, and acts as a structural protein in the cytoskeleton. It is expressed in astrocytes in brain and is often used as an astrocyte marker. GFAP is believed to be involved in many CNS processes including cell communication and mitosis. GFAP has been found to be involved in Alexander disease and Wernicke's encephalopathy.

Synonyms

Glial fibrillary acidic protein (GFAP)

Gene Name

GFAP

UniProt

P14136

Host

Guinea Pig

Reactivity

Drosophila, Guinea Pig, Human, Mouse, Polar Bear, and Rat

Immunogen

Synthetic peptide amino acids 411-422 (KTVEMRDGEVIK) of human GFAP (accession number P14136)

Target

GFAP

Clonality

Recombinant

Isotype

IgG

Clone

N206A/8

Type

Primary Antibodies

Applications

ELISA, ICC, IHC, WB

Concentration

1 mg/mL

Format

Purified by affinity chromatography

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Molecular Weight

50 kDa

Shipping Conditions

Shipped on ice packs

Storage Conditions

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of our NeuroMab clone N206A/8 with guinea pig IgG heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N206A/8 but can be detected using standard anti-guinea pig secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

IHC Dilution

0.3888888888888889

WB Dilution

0.7361111111111112

Specificity

Cross-reacts with GFAP-R416W and other GFAP mutant proteins. Does not cross-react with other proteins (based on KO validation results) .

ICC Dilution

0.3888888888888889

Quality Control

Each new lot of antibody is quality control tested by Western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Brand

Antibodies Inc

Recommended Usage

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Physical Properties

Liquid

Immunogen Species

Human

Trial Size

1

Conjugate

Unconjugated

Frequently Asked Questions

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