Oroxylin A-7-O-glucuronide

Oroxylin A-7-O-glucuronide (oroxyloside) is an orally active flavonoid glucuronide and metabolite of Oroxylin A (HY-N0560) . Oroxylin A-7-O-glucuronide can be extracted from the dried root of Scutellaria baicalensis. Oroxylin A-7-O-glucuronide exhibits prolyl oligopeptidase inhibitory activity. Oroxylin A-7-O-glucuronide inhibits the JNK pathway, upregulates PPARγ, and inhibits NF-κB p65 nuclear translocation. Oroxylin A-7-O-glucuronide reduces cytokine (IL-1β, IL-6) production. Oroxylin A-7-O-glucuronide exhibits anti-angiogenic, anti-tumor (glioma, liver cancer), anti-inflammatory, and hepatoprotective activities[1][2][3][4][5][6].

Product Specifications

CAS Number

[36948-76-2]

Product Name Alternative

Oroxyloside; Oroxylin A-7-O-β-D-glucuronide

UNSPSC

12352005

Hazard Statement

H302

Target

Drug Metabolite; Interleukin Related; JNK; NF-κB; PPAR; Prolyl Endopeptidase (PREP)

Type

Natural Products

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/oroxylin-a-7-o-glucuronide.html

Purity

99.83

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=C2C(OC(C3=CC=CC=C3)=CC2=O)=CC(O[C@@H]4O[C@@H]([C@@H](O)[C@H](O)[C@H]4O)C(O)=O)=C1OC

Molecular Formula

C22H20O11

Molecular Weight

460.39

Precautions

H302

References & Citations

[1]Marques MR, et al. Flavonoids with prolyl oligopeptidase inhibitory activity isolated from Scutellaria racemosa Pers. Fitoterapia. 2010 Sep;81 (6) :552-6.|[2]Zhao K, et al. Oroxyloside inhibits angiogenesis through suppressing internalization of VEGFR2/Flk-1 in endothelial cells. J Cell Physiol. 2018 Apr;233 (4) :3454-3464. |[3]Xu ZF, et al. Oroxyloside inhibits human glioma progression by suppressing proliferation, metastasis and inducing apoptosis related pathways. Biomed Pharmacother. 2018 Jan;97:1564-1574. |[4]Liao Y, et al. Oroxyloside ameliorates acetaminophen-induced hepatotoxicity by inhibiting JNK related apoptosis and necroptosis. J Ethnopharmacol. 2020 Aug 10;258:112917. |[5]Wang X, et al. Oroxyloside prevents dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB pathway through PPARγ activation. Biochem Pharmacol. 2016 Apr 15;106:70-81. |[6]Liu Y, et al. Oroxyloside inhibits liver fibrosis and hepatocarcinogenesis dependent on hepatocyte-specific knockout of Atg5. Phytomedicine. 2025 Sep;145:157053.