L-Ascorbic acid 2-phosphate (magnesium hydrate)

L-ascorbic acid 2-phosphate (2-Phospho-L-ascorbic acid) magnesium hydrate is a long-acting vitamin C derivative that can stimulate collagen formation and expression. L-ascorbic acid 2-phosphate magnesium hydrate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs) . L-ascorbic acid 2-phosphate magnesium hydrate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation[1][2][3].

Product Specifications

CAS Number

[1713265-25-8]

Product Name Alternative

2-Phospho-L-ascorbic acid (magnesium hydrate) ; LAA2P (magnesium hydrate)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Phosphatase; Reactive Oxygen Species (ROS)

Type

Biochemical Assay Reagents

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/l-ascorbic-acid-2-phosphate-magnesium-hydrate.html

Purity

99.63

Solubility

H2O : 5 mg/mL (ultrasonic)

Smiles

O=P(O)(O)OC1=C([C@@](OC1=O)([H])[C@@H](O)CO)O.[Mg].O.[x].[3/2]

Molecular Formula

C6H9O9P.xH2O.3/2Mg

Precautions

H302, H315, H319, H335

References & Citations

[1]Shima N, et al. Increased proliferation and replicative lifespan of isolated human corneal endothelial cells with L-ascorbic acid 2-phosphate.Invest Ophthalmol Vis Sci. 2011 Nov 7;52 (12) :8711-7.|[2]Kurata S, et al. Epidermal growth factor inhibits transcription of type I collagen genes and production of type I collagen in cultured human skin fibroblasts in the presence and absence of L-ascorbic acid 2-phosphate, a long-acting vitamin C derivative.J Biol Chem. 1991 May 25;266 (15) :9997-10003.|[3]Kyllönen L, et al. Effects of different serum conditions on osteogenic differentiation of human adipose stem cells in vitro.Stem Cell Res Ther. 2013 Feb 15;4 (1) :17.