Anti-CEP55 Antibody Picoband® APC Conjugated

The 55 kDa centrosomal protein (CEP55) is a widely expressed centrosome and midbody-associated protein that regulates cytokinesis, including completion of the final step during cytokinesis known as abscission (1,2) . CEP55 activity during abscission is negatively regulated by p53 through Polo-like kinase 1 (3,4) . The breast and ovarian cancer DNA repair protein BRCA2 interacts with CEP55 and plays a regulatory role during abscission (5) . Research studies demonstrate that CEP55 is also involved in the regulation of Akt signaling, autophagy, and may be a biomarker in human cancer (reviewed in 6) . The correlated overexpression of CEP55, the transcription factor FoxM1, and the HELLS helicase is seen in head and neck squamous cell carcinoma (7,8) . Additional studies demonstrate that CEP55 expression regulates cell proliferation in gastric carcinoma (9) .

Recommended applications are based on the parent unconjugated antibody. Customers may select suitable applications according to their experimental needs.