Anti-Catenin Gamma (Plakoglobin) Jup Antibody (Monoclonal, 35J59)

Junction Plakoglobin (JUP), also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. Gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.

Store at -20 ̊C for one year from date of receipt. After reconstitution, at 4 ̊C for one month. It can also be aliquotted and stored frozen at -20 ̊C for six months. Avoid repeated freeze-thaw cycles.