Dalargin

Dalargin is a potent δ-opioid receptor agonist. Dalargin mitigates Gentamicin (HY-A0276) -induced cell death. Dalargin shows nephroprotective effects on Gentamicin (HY-A0276A) -induced kidney injury. Dalargin shows antiulcer activity[1][2][3].

Product Specifications

CAS Number

[81733-79-1]

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dalargin.html

Purity

99.52

Solubility

DMSO : ≥ 100 mg/mL

Smiles

N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC(CNC([C@@H](C)NC([C@@H](N)CC1=CC=C(C=C1)O)=O)=O)=O)CC2=CC=CC=C2)=O)=O

Molecular Formula

C35H51N9O8

Molecular Weight

725.83

References & Citations

[1]Titov MI, et al. Dalargin--a peptidnyĭ preparat s tsitoprotektivnym deĭstviem [Dalargin--a peptide preparation with cytoprotective action]. Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1985;8 (2) :72-6.|[2]Plotnikov EY, et al. Nephroprotective effect of GSK-3β inhibition by lithium ions and δ-opioid receptor agonist dalargin on gentamicin-induced nephrotoxicity. Toxicol Lett. 2013 Jul 18;220 (3) :303-8.|[3]Polonskiĭ VM, et al. Mesto prilozheniia (tsentral'noe ili perifericheskoe) protivoiazvennogo deĭstviia sinteticheskogo analoga éndogennykh opioidov dalargina v éksperimental'noĭ modeli tsisteaminovykh duodenal'nykh iazv u krys [The site (central or peripheral) of the anti-ulcer action of dalargin, a synthetic analog of endogenous opioids in an experimental model of cysteamine-induced duodenal ulcer in rats]. Biull Eksp Biol Med. 1987 Apr;103 (4) :433-4.