LY2880070

LY2880070 is an orally active CHK1 inhibitor, IC50 [1][2].

Product Specifications

CAS Number

[1375637-35-6]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Checkpoint Kinase (Chk)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ly2880070.html

Purity

99.77

Solubility

DMSO : 160 mg/mL (ultrasonic)

Smiles

COC1=C(C=CC(C)=N1)C2=CC(NC3=NC(O[C@@H]4CCCNC4)=CN=C3)=NN2

Molecular Formula

C19H23N7O2

Molecular Weight

381.43

Precautions

H315, H319, H335

References & Citations

[1]Quincy S, et al. A phase Ib study of oral Chk1 inhibitor LY2880070 in combination with gemcitabine in patients with advanced or metastatic cancer. Journal of Clinical Oncology 2020 38:15_suppl, 3581.|[2]Kailong Jiang, et al. Functions and inhibitors of CHK1 in cancer therapy. Medicine in Drug Discovery. Volume 22, June 2024, 100185.