KM11060

KM11060 is a corrector of the F508 deletion (F508del) -cystic fibrosis transmembrane conductance regulator (CFTR) trafficking defect. KM11060 can be used for the research of F508del-CFTR processing defect and development of cystic fibrosis research[1].

Product Specifications

CAS Number

[774549-97-2]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Autophagy; CFTR

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/KM11060.html

Purity

98.71

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=S(N1CCN(C2=CC=NC3=CC(Cl)=CC=C23)CC1)(C4=CC=C(Cl)C=C4)=O

Molecular Formula

C19H17Cl2N3O2S

Molecular Weight

422.33

Precautions

H315, H319, H335

References & Citations

[1]Robert R, et al. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73 (2) :478-89.|[2]Wu H, et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar 26;9 (3) :e93003.