KM11060
Product Specifications
UNSPSC Description
KM11060 is a corrector of the F508 deletion (F508del)-cystic fibrosis transmembrane conductance regulator (CFTR) trafficking defect. KM11060 can be used for the research of F508del-CFTR processing defect and development of cystic fibrosis research[1].
Target Antigen
Autophagy; CFTR
Type
Reference compound
Related Pathways
Autophagy;Membrane Transporter/Ion Channel
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/KM11060.html
Purity
98.71
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(N1CCN(C2=CC=NC3=CC(Cl)=CC=C23)CC1)(C4=CC=C(Cl)C=C4)=O
Molecular Weight
422.33
References & Citations
[1]Robert R, et al. Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect. Mol Pharmacol. 2008 Feb;73(2):478-89.|[2]Wu H, et al. Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. PLoS One. 2014 Mar 26;9(3):e93003.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19970/KM11060-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19970/KM11060-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
774549-97-2
Available Sizes
Curated Selection
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