Verdiperstat

Verdiperstat (AZD3241) is a selective, irreversible and orally active myeloperoxidase (MPO) inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.

Product Specifications

CAS Number

890655-80-8

Product Name Alternative

AZD3241

UNSPSC

12352005

Hazard Statement

H302

Target

Glutathione Peroxidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Verdiperstat.html

Purity

99.69

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1)C(NC=C2)=C2N(CCOC(C)C)C1=S

Molecular Formula

C11H15N3O2S

Molecular Weight

253.32

Precautions

H302

References & Citations

[1]Johnström P, et al. Development of rapid multistep carbon-11 radiosynthesis of the myeloperoxidase inhibitor AZD3241 to assess brain exposure by PET microdosing. Nucl Med Biol. 2015 Jun;42 (6) :555-60.|[2]Jucaite A, et al. Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson's disease. Brain. 2015 Sep;138 (Pt 9) :2687-700.