15 (S) -HPETE

15 (S) -HPETE is a precursor of 15 (S) -HETE (HY-113336) . 15 (S) -HPETE is a product of Arachidonic acid (HY-109590) in the 15-lipoxygenase pathway. 15 (S) -HPETE reduces Bcl-2, Akt, and phosphorylated Akt protein levels. 15 (S) -HPETE induces Apoptosis. 15 (S) -HPETE antagonizes the angiogenic effects of 15 (S) -HETE. 15 (S) -HPETE exhibits antitumor effects against chronic myeloid leukemia. 15 (S) -HPETE can be used in adipose tissue explant studies[1][2][3].

Product Specifications

CAS Number

[70981-96-3]

UNSPSC

12352211

Hazard Statement

H225, H319

Target

Akt; Apoptosis; Bcl-2 Family; Drug Metabolite

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/15-s-hpete.html

Concentration

297.20 μM * 250 μL in Ethanol

Purity

97.3

Smiles

CCCCC[C@H](OO)/C=C/C=C\C/C=C\C/C=C\CCCC(O)=O

Molecular Formula

C20H32O4

Molecular Weight

336.47

Precautions

H225, H319

References & Citations

[1]Soumya SJ, et al. Effect of 15-lipoxygenase metabolites on angiogenesis: 15 (S) -HPETE is angiostatic and 15 (S) -HETE is angiogenic. Inflamm Res. 2012 Jul;61 (7) :707-18. |[2]Soumya SJ, et al. 15-LOX metabolites and angiogenesis: angiostatic effect of 15 (S) -HPETE involves induction of apoptosis in adipose endothelial cells. PeerJ. 2014 Oct 21;2:e635. |[3]Mahipal SV, et al. Effect of 15-lipoxygenase metabolites, 15- (S) -HPETE and 15- (S) -HETE on chronic myelogenous leukemia cell line K-562: reactive oxygen species (ROS) mediate caspase-dependent apoptosis. Biochem Pharmacol. 2007 Jul 15;74 (2) :202-14.