OSU-ERb-12
Product Specifications
UNSPSC Description
OSU-ERb-12 is a ERβ agonist, and suppress ovarian cancer cell proliferation in vitro and in vivo. OSU-ERb-12 decreases the expression of Snail[1][2].
Target Antigen
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/osu-erb-12.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C2345[BH]678[BH]9%10%11[BH]%12%13%14[BH]962[BH]%123%15[BH]%13%16%17C%10%14%18([C@@H](O)CCCCCC)[BH]%117%19[BH]%18%16%20[BH]%1984[BH]%17%15%205
Molecular Weight
350.51
References & Citations
[1]Sedlák D, et al. Structure-Activity Relationship of para-Carborane Selective Estrogen Receptor β Agonists. J Med Chem. 2021;64(13):9330-9353. |[2]Banerjee A, et al. A Novel Estrogen Receptor β Agonist Diminishes Ovarian Cancer Stem Cells via Suppressing the Epithelial-to-Mesenchymal Transition. Cancers (Basel). 2022;14(9):2311. Published 2022 May 6.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161253/OSU-ERb-12-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161253/
Clinical Information
No Development Reported
CAS Number
2088837-20-9
Curated Selection
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