OSU-ERb-12

Product Specifications

CAS Number

[2088837-20-9]

UNSPSC Description

OSU-ERb-12 is a ERβ agonist, and suppress ovarian cancer cell proliferation in vitro and in vivo. OSU-ERb-12 decreases the expression of Snail[1][2].

Target Antigen

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/osu-erb-12.html

Solubility

10 mM in DMSO

Smiles

OC(C=C1)=CC=C1C2345[BH]678[BH]9%10%11[BH]%12%13%14[BH]962[BH]%123%15[BH]%13%16%17C%10%14%18([C@@H](O)CCCCCC)[BH]%117%19[BH]%18%16%20[BH]%1984[BH]%17%15%205

Molecular Weight

350.51

References & Citations

[1]Sedlák D, et al. Structure-Activity Relationship of para-Carborane Selective Estrogen Receptor β Agonists. J Med Chem. 2021;64(13):9330-9353. |[2]Banerjee A, et al. A Novel Estrogen Receptor β Agonist Diminishes Ovarian Cancer Stem Cells via Suppressing the Epithelial-to-Mesenchymal Transition. Cancers (Basel). 2022;14(9):2311. Published 2022 May 6.